Bone Mineral Density and Fat-Soluble Vitamin Status in Adults with Cystic Fibrosis Undergoing Lung Transplantation: A Pilot Study
Publication: Canadian Journal of Dietetic Practice and Research
19 July 2016
Abstract
Purpose: Patients with cystic fibrosis (CF) often experience low bone mineral density (BMD) pre- and post-lung transplantation (LTX). The study purpose was to describe BMD and micronutrient status in adults with CF pre- and post-LTX.
Methods: Twelve patients with CF (29 ± 8 years) were recruited from the CF clinic at the University of Alberta Lung Transplant Program. BMD and vitamins A, D, E, K status, and parathyroid hormone were measured pre- and post-LTX.
Results: No significant differences pre- and post-LTX were observed at the different bone sites measured (lumber–spine, femoral–neck (FN), hip, and femoral–trochlea) (P > 0.05). BMD T-scores (<−2) was present in lumbar–spine, FN, hip, and femoral–trochlea in 33%, 17%, 17%, and 25% of individuals pre-LTX and 58%, 33%, 58%, and 33% of individuals post-LTX, respectively. More than 50% of patients had suboptimal vitamin K levels (PIVKA-II values >3 ng/mL) pre- and post-LTX.
Conclusion: Adults with CF pre- and post-LTX had reduced BMD and suboptimal vitamin K status.
Résumé
Objectif. Les patients atteints de fibrose kystique (FK) ont souvent une densité minérale osseuse (DMO) faible avant et après la transplantation pulmonaire (TP). L’objectif de l’étude était de décrire la DMO et l’état nutritionnel en micronutriments des adultes atteints de FK avant et après la TP.
Méthodes. Douze patients atteints de FK (29 ± 8 ans) ont été recrutés à la clinique de FK du programme de transplantation pulmonaire de l’Université de l’Alberta. La DMO et l’état nutritionnel en vitamines A, D, E et K, et l’hormone parathyroïde ont été mesurés avant et après la TP.
Résultats. Aucune différence significative n’a été observée avant et après la TP aux différents sites osseux mesurés (rachis lombaire, col fémoral, hanche et trochlée fémorale) (p > 0,05). Des scores T de la DMO (<−2) étaient présents dans le rachis lombaire, le col fémoral, la hanche et la trochlée fémorale chez 33 %, 17 %, 17 % et 25 % des personnes avant la TP et chez 58 %, 33 %, 58 % et 33 % des personnes après la TP, respectivement. Plus de 50% des patients avaient des taux de vitamine K sous-optimaux (concentrations de PIVKA-II > 3 ng/ml) avant et après la TP.
Conclusion. Les adultes atteints de FK avaient une DMO réduite et un taux de vitamine K sous-optimal avant et après la TP.
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Published In
Canadian Journal of Dietetic Practice and Research
Volume 77 • Number 4 • December 2016
Pages: 199 - 202
History
Version of record online: 19 July 2016
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Grace Hubert RD BSc, Theresa Tam Chung RD BSc, Connie Prosser PhD FCACB, Dale Lien MD, Justin Weinkauf MD, Neil Brown MD, Marianne Goodvin RN BNSc, Kathy Jackson RN BNSc, Joan Tabak RN, Josette Salgado RN BNSc, Abeer Salman Alzaben MSc, and Diana R. Mager PhD MSc RD. 2016. Bone Mineral Density and Fat-Soluble Vitamin Status in Adults with Cystic Fibrosis Undergoing Lung Transplantation: A Pilot Study. Canadian Journal of Dietetic Practice and Research.
77(4): 199-202. https://doi.org/10.3148/cjdpr-2016-014
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