Nutrition Care of Critically Ill Patients with Leukemia: A Retrospective Study

Publication: Canadian Journal of Dietetic Practice and Research
15 November 2018

Abstract

Adults with acute leukemia (AL) are at high risk of malnutrition due to their disease and treatment side effects and may be admitted to the intensive care unit (ICU), further increasing the risk of malnutrition. Although ICU care includes some form of nutrition, patients typically receive less than prescribed energy and protein. Our objective was to characterize the nutrition care for critically ill patients with AL. We completed a retrospective review of adults with AL admitted to the Medical/Surgical ICU >24 hours. Descriptive statistics were performed on collected data including: demographics, APACHE II and Nutric scores, nutrition therapy, reasons for withholding nutrition, and mortality status at discharge. Data were collected on 154 AL patients with an average APACHE II score of 27 and Nutric score of 5.96. ICU mortality was 36%. Enteral nutrition (EN) was most commonly prescribed. Patients on EN received 55% of energy and 51% of protein prescribed. EN was commonly withheld for airway management and gastrointestinal impairment. Patients with AL received low amounts of energy and protein in the ICU and had a high Nutric score. Strategies and barriers to improve protein intake in this population are identified.

Résumé

Les adultes atteints de leucémie aiguë (LA) présentent un risque élevé de malnutrition en raison de leur maladie et des effets secondaires des traitements, et doivent parfois être admis dans une unité de soins intensifs (USI), ce qui augmente davantage le risque de malnutrition. Bien que les soins offerts dans les USI comprennent une certaine forme de nutrition, les patients reçoivent généralement un apport énergétique et en protéines inférieur à celui recommandé. Notre objectif était de caractériser les soins en nutrition offerts aux patients atteints de LA grave. Nous avons réalisé un examen rétrospectif des adultes atteints de LA admis dans une USI médicale ou chirurgicale pendant plus de 24 heures. Des analyses statistiques descriptives ont été menées sur les données recueillies, notamment les données démographiques, les scores APACHE II et Nutric, le traitement nutritionnel, les raisons de l’arrêt de l’alimentation et le statut de mortalité lors du congé de l’hôpital. Les données ont été recueillies auprès de 154 patients atteints de LA. Le score APACHE II moyen était de 27, et le score Nutric moyen, de 5,96. Le taux de mortalité en USI était de 36 %. L’alimentation entérale (AE) était la plus communément prescrite. Les patients recevant une AE recevaient 55 % de l’apport énergétique et 51 % de l’apport en protéine recommandé. L’AE était le plus souvent arrêtée pour des raisons d’assistance respiratoire et de défaillance gastro-intestinale. Les patients atteints de LA recevaient de faibles quantités d’énergie et de protéines à l’USI et présentaient un score NUTRIC élevé. Les stratégies et obstacles relatifs à l’amélioration de l’apport en protéines de cette population sont ciblés.

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Financial support: No financial support was received for this research.
Conflict of interest: The authors have no conflicts of interest to declare.

References

1
Esper DH and Harb WA. The cancer cachexia syndrome: a review of metabolic and clinical manifestations. Nutr Clin Pract. 2005;20(4):369–76.
2
Trinkaus MA, Lapinsky SE, Crump M, Keating A, Reece DE, Chen C, et al. Predictors of mortality in patients undergoing autologous hematopoietic cell transplantation admitted to the intensive care unit. Bone Marrow Transplant. 2009;43(5):411–5.
3
Heyland DK, Dhaliwal R, Wang M, and Day AG. The prevalence of iatrogenic underfeeding in the nutritionally ‘at-risk’ critically ill patient: results of an international, multicenter, prospective study. Clin Nutr. 2015;34(4):659–66.
4
National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Rice TW, Wheeler AP, Thompson BT, Steingrub J, Hite RD, Moss M, et al. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA. 2012;307(8):795–803.
5
Arabi YM, Aldawood AS, Haddad SH, Al-Dorzi HM, Tamim HM, Jones G, et al. Permissive underfeeding or standard enteral feeding in critically ill adults. N Engl J Med. 2015;372(25):2398–408.
6
Arabi YM, Aldawood AS, Al-Dorzi HM, Tamim HM, Haddad SH, Jones G, et al. Permissive underfeeding or standard enteral feeding in high- and low-nutritional-risk critically ill adults. Post hoc analysis of the PermiT trial. Am J Resp Crit Care Med. 2017;195(5):652–62.
7
Wei X, Day AG, Ouellette-Kuntz H, and Heyland DK. The association between nutritional adequacy and long-term outcomes in critically ill patients requiring prolonged mechanical ventilation: a multicenter cohort study. Crit Care Med. 2015;43(8):1569–79.
8
Nicolo M, Heyland DK, Chittams J, Sammarco T, and Compher C. Clinical outcomes related to protein delivery in a critically ill population: a multicenter, multinational observation study. JPEN J Parenter Enteral Nutr. 2016;40(1):45–51.
9
Cahill NE, Murch L, Cook D, Heyland DK, and Canadian Critical Care Trials Group. Improving the provision of enteral nutrition in the intensive care unit: a description of a multifaceted intervention tailored to overcome local barriers. Nutr Clin Pract. 2014;29(1):110–7.
10
McClave SA, Martindale RG, Vanek VW, McCarthy M, Roberts P, Taylor B, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr. 2009;33(3):277–316.
11
Knaus WA, Zimmerman JE, Wagner DP, Draper EA, and Lawrence DE. APACHE—acute physiology and chronic health evaluation: a physiologically based classification system. Crit Care Med. 1981;9(8):591–7.
12
Heyland DK, Dhaliwal R, Jiang X, and Day A. Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool. Crit Care. 2011;15:R268.
13
Critical Care Nutrition (CCN). Kingston, ON: Clinical Evaluative Research Unit, Kingston General Hospital/Queen’s University; c2018 [cited 2018 May 11]. Available from: https://www.criticalcarenutrition.com/.
14
Kuslapuu M, Jogela K, Starkopf J, and Reintam Blaser A. The reasons for insufficient enteral feeding in an intensive care unit: a prospective observational study. Intensive Crit Care Nurs. 2015;31(5):309–14.
15
MacEachern KN, Vermeer A, and Hochman C. Evaluation of an enteral nutrition protocol in the medical/surgical ICU (abstract). Crit Care Med. 2009;37(12 Suppl.):A124.
16
Reignier J, Mercier E, Le Gouge A, Boulain T, Desachy A, Bellec F, et al. Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial. JAMA. 2013;309(3):249–56.
17
Heyland DK, Dhaliwal R, Lemieux M, Wang M, and Day AG. Implementing the PEP uP Protocol in critical care units in Canada: results of a multicenter, quality improvement study. JPEN J Parenter Enteral Nutr. 2015;39(6):698–706.
18
Rahman A, Hasan RM, Agarwala R, Martin C, Day AG, and Heyland DK. Identifying critically-ill patients who will benefit most from nutritional therapy: further validation of the “modified NUTRIC” nutritional risk assessment tool. Clin Nutr. 2016;35(1):158–62.
19
Lee ZY, Noor Airini I, and Barakatun-Nisak MY. Relationship of energy and protein adequacy with 60-day mortality in mechanically ventilated critically ill patients: a prospective observational study. Clin Nutr. 2018 Aug;37(4):1264–70.
20
Mukhopadhyay A, Henry J, Ong V, Leong CS, Teh AL, van Dam RM, et al. Association of modified NUTRIC score with 28-day mortality in critically ill patients. Clin Nutr. 2017;36(4):1143–8.
21
Mendes R, Policarpo S, Fortuna P, Alves M, Virella D, Heyland DK, et al. Nutritional risk assessment and cultural validation of the modified NUTRIC score in critically ill patients—a multicenter prospective cohort study. J Crit Care. 2017;37:45–9.
22
Marks GC, Hughes MC, and van der Pols JC. Relative validity of food intake estimates using a food frequency questionnaire is associated with sex, age, and other personal characteristics. J Nutr. 2006;136(2):459–65.
23
Philipson TJ, Snider JT, Lakdawalla DN, Stryckman B, and Goldman DP. Impact of oral nutritional supplementation on hospital outcomes. Am J Manag Care. 2013;19(2):121–8.
24
Canadian Agency for Drugs and Technologies in Health Rapid Response Reports. The medication pass nutritional supplement program in patients receiving medication: a review of clinical effectiveness and guidelines. Ottawa, ON: Canadian Agency for Drugs and Technologies in Health; 2015 Mar.

Information & Authors

Information

Published In

cover image Canadian Journal of Dietetic Practice and Research
Canadian Journal of Dietetic Practice and Research
Volume 80Number 1March 2019
Pages: 34 - 38

History

Version of record online: 15 November 2018

Authors

Affiliations

Kristen N. MacEachern MSc, RD
Departments of Clinical Nutrition and Critical Care, Mount Sinai Hospital, Toronto, ON
Alan P. Kraguljac MSc
Department of Critical Care, Mount Sinai Hospital, Toronto, ON
Sangeeta Mehta MD, FRCP(C)
Department of Medicine and Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital and University of Toronto, Toronto, ON

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